{"product_id":"tb500","title":"TB500","description":"\u003ch2 dir=\"auto\" class=\"PDq2pG_selectionAnchorContainer\"\u003eTB-500 – Research Peptide\u003cspan class=\"PDq2pG_selectionAnchor\"\u003e\u003c\/span\u003e\n\u003c\/h2\u003e\n\u003ch3 dir=\"auto\"\u003eThymosin Beta-4–Derived Peptide for Scientific Research\u003c\/h3\u003e\n\u003cp dir=\"auto\"\u003e\u003cstrong\u003eTB-500\u003c\/strong\u003e is a synthetic peptide derived from a biologically active region of \u003cstrong\u003eThymosin Beta-4 (Tβ4)\u003c\/strong\u003e, a naturally occurring peptide involved in actin regulation and several cellular processes associated with tissue biology.\u003c\/p\u003e\n\u003cp dir=\"auto\"\u003eTB-500 has attracted research interest in areas including \u003cstrong\u003ecell migration, cytoskeletal dynamics, tissue-repair mechanisms, angiogenesis and regenerative biology\u003c\/strong\u003e.\u003c\/p\u003e\n\u003cp dir=\"auto\"\u003eMuch of the biological background associated with TB-500 originates from research conducted on its parent molecule, Thymosin Beta-4. It is therefore important to distinguish experimental findings involving full-length Tβ4 from evidence directly involving the TB-500 fragment.\u003c\/p\u003e\n\u003cp dir=\"auto\"\u003e\u003cstrong\u003eICAME Pharmacy TB-500 is intended strictly for laboratory research and development purposes. It is not intended for human or veterinary use.\u003c\/strong\u003e\u003c\/p\u003e\n\u003ctable width=\"100%\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003e\n\u003cp\u003e \u003cspan class=\"whatyouget__label\"\u003eWhat the parcel contains\u003c\/span\u003e\u003cspan class=\"whatyouget__label\"\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"whatyouget__text\"\u003eOne sealed vial of TB500 10 mg, lyophilised, without individual labelling.\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003ctable width=\"100%\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003e\n\u003cp\u003e \u003cspan class=\"whatyouget__label\"\u003eWhat you also need\u003c\/span\u003e\u003cspan class=\"whatyouget__label\"\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"whatyouget__text\"\u003eBacteriostatic water for reconstitution and 2 ml precision syringes graduated in 100 units, sold separately.\u003cspan\u003e \u003c\/span\u003e\u003cstrong\u003eThe vial alone cannot be used as is.\u003c\/strong\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp class=\"whatyouget__text\"\u003e \u003c\/p\u003e\n\u003ch2 dir=\"auto\"\u003eWhat is TB-500?\u003c\/h2\u003e\n\u003cp dir=\"auto\"\u003eTB-500 is a synthetic peptide associated with the actin-binding region of \u003cstrong\u003eThymosin Beta-4\u003c\/strong\u003e, one of the most abundant members of the beta-thymosin family.\u003c\/p\u003e\n\u003cp dir=\"auto\"\u003eThymosin Beta-4 is a naturally occurring \u003cstrong\u003e43-amino-acid peptide\u003c\/strong\u003e found in many mammalian tissues. One of its best-characterized biological functions is its interaction with \u003cstrong\u003eG-actin\u003c\/strong\u003e, through which it contributes to regulation of the actin cytoskeleton.\u003c\/p\u003e\n\u003cp dir=\"auto\"\u003eActin is fundamental to cellular structure and movement. Changes in actin polymerization and organization influence processes such as:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eCell migration\u003c\/li\u003e\n\u003cli\u003eCell adhesion\u003c\/li\u003e\n\u003cli\u003eCytoskeletal organization\u003c\/li\u003e\n\u003cli\u003eTissue remodeling\u003c\/li\u003e\n\u003cli\u003eEndothelial-cell behavior\u003c\/li\u003e\n\u003cli\u003eCellular differentiation\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp dir=\"auto\"\u003eThese properties have made the Tβ4 pathway an important subject in experimental regenerative and cellular biology. \u003cspan class=\"contents\"\u003e\u003cspan class=\"\"\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003chr\u003e\n\u003ch2 dir=\"auto\"\u003eTB500 and Thymosin Beta-4\u003c\/h2\u003e\n\u003cp dir=\"auto\"\u003eAn important distinction should be made between \u003cstrong\u003eTB-500 and full-length Thymosin Beta-4\u003c\/strong\u003e.\u003c\/p\u003e\n\u003cp dir=\"auto\"\u003eThey are related, but they should not be considered scientifically interchangeable.\u003c\/p\u003e\n\u003cp dir=\"auto\"\u003eFull-length Tβ4 consists of 43 amino acids and has been investigated extensively in experimental models. TB-500 refers to a shorter synthetic fragment associated with the biologically important actin-binding region of the parent peptide.\u003c\/p\u003e\n\u003cp dir=\"auto\"\u003eConsequently, findings from studies involving full-length Tβ4 should be regarded as \u003cstrong\u003emechanistic and biological background\u003c\/strong\u003e rather than direct evidence that TB-500 produces identical effects.\u003c\/p\u003e\n\u003cp dir=\"auto\"\u003eThis distinction is particularly important when evaluating research involving tissue repair, angiogenesis and wound biology.\u003c\/p\u003e\n\u003chr\u003e\n\u003ch2 dir=\"auto\"\u003eActin and Cytoskeletal Regulation\u003c\/h2\u003e\n\u003cp dir=\"auto\"\u003eOne of the most extensively studied characteristics of Thymosin Beta-4 is its interaction with \u003cstrong\u003eG-actin (globular actin)\u003c\/strong\u003e.\u003c\/p\u003e\n\u003cp dir=\"auto\"\u003eTβ4 can bind G-actin and influence the equilibrium between individual actin molecules and polymerized \u003cstrong\u003eF-actin filaments\u003c\/strong\u003e.\u003c\/p\u003e\n\u003cp dir=\"auto\"\u003eThe actin cytoskeleton is essential for numerous cellular processes, including:\u003c\/p\u003e\n\u003cp dir=\"auto\"\u003e\u003cstrong\u003eCell movement → Cell adhesion → Cell shape → Migration → Tissue organization\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp dir=\"auto\"\u003eThrough this relationship with actin biology, Tβ4 and related peptide sequences have become useful subjects for research into cellular movement and tissue-remodeling mechanisms. \u003cspan class=\"contents\"\u003e\u003cspan class=\"\"\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003chr\u003e\n\u003ch2 dir=\"auto\"\u003ePotential Research Areas\u003c\/h2\u003e\n\u003cp dir=\"auto\"\u003eTB500 and the broader Thymosin Beta-4 pathway are of interest across several areas of experimental research.\u003c\/p\u003e\n\u003ch3 dir=\"auto\"\u003eTissue Repair Biology\u003c\/h3\u003e\n\u003cp dir=\"auto\"\u003eThymosin Beta-4 has been studied extensively in experimental models of tissue repair.\u003c\/p\u003e\n\u003cp dir=\"auto\"\u003eAnimal studies have reported changes in re-epithelialization, collagen deposition, cellular migration and angiogenesis following Tβ4 exposure.\u003c\/p\u003e\n\u003cp dir=\"auto\"\u003eThese observations have contributed to scientific interest in Tβ4-derived peptides for studying the molecular mechanisms involved in \u003cstrong\u003etissue remodeling and regenerative biology\u003c\/strong\u003e. \u003cspan class=\"contents\"\u003e\u003cspan class=\"\"\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003chr\u003e\n\u003ch2 dir=\"auto\"\u003eCell Migration\u003c\/h2\u003e\n\u003cp dir=\"auto\"\u003eCell migration is fundamental to tissue development and repair.\u003c\/p\u003e\n\u003cp dir=\"auto\"\u003eExperimental studies involving Tβ4 have demonstrated effects on endothelial-cell migration. Research using human endothelial cells found increased directional migration and other cellular behaviors associated with angiogenic processes.\u003c\/p\u003e\n\u003cp dir=\"auto\"\u003eBecause actin cytoskeleton remodeling is fundamental to cell movement, the Tβ4 actin-binding region remains an interesting target for experimental investigation. \u003cspan class=\"contents\"\u003e\u003cspan class=\"\"\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003chr\u003e\n\u003ch2 dir=\"auto\"\u003eAngiogenesis Research\u003c\/h2\u003e\n\u003cp dir=\"auto\"\u003eAnother major research area associated with Thymosin Beta-4 is \u003cstrong\u003eangiogenesis\u003c\/strong\u003e, the biological process through which new blood vessels develop from existing vasculature.\u003c\/p\u003e\n\u003cp dir=\"auto\"\u003eAngiogenesis plays an important role in:\u003c\/p\u003e\n\u003cp dir=\"auto\"\u003e\u003cstrong\u003eTissue development • Wound repair • Tissue remodeling • Vascular biology\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp dir=\"auto\"\u003eExperimental research has demonstrated that the actin-binding region of Tβ4 contributes to its angiogenic activity.\u003c\/p\u003e\n\u003cp dir=\"auto\"\u003eStudies have reported effects involving endothelial-cell migration, adhesion, vessel sprouting and formation of vascular structures.\u003c\/p\u003e\n\u003cp dir=\"auto\"\u003eThese observations make the Tβ4 pathway relevant to researchers investigating the relationship between \u003cstrong\u003ecytoskeletal dynamics and vascular development\u003c\/strong\u003e. \u003cspan class=\"contents\"\u003e\u003cspan class=\"\"\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003chr\u003e\n\u003ch2 dir=\"auto\"\u003eTissue Remodeling Research\u003c\/h2\u003e\n\u003cp dir=\"auto\"\u003eTissue repair involves a complex sequence of biological events rather than a single pathway.\u003c\/p\u003e\n\u003cp dir=\"auto\"\u003eThese processes can include:\u003c\/p\u003e\n\u003cp dir=\"auto\"\u003e\u003cstrong\u003eCell Migration\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp dir=\"auto\"\u003e↓\u003c\/p\u003e\n\u003cp dir=\"auto\"\u003e\u003cstrong\u003eExtracellular Matrix Remodeling\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp dir=\"auto\"\u003e↓\u003c\/p\u003e\n\u003cp dir=\"auto\"\u003e\u003cstrong\u003eAngiogenesis\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp dir=\"auto\"\u003e↓\u003c\/p\u003e\n\u003cp dir=\"auto\"\u003e\u003cstrong\u003eCollagen Organization\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp dir=\"auto\"\u003e↓\u003c\/p\u003e\n\u003cp dir=\"auto\"\u003e\u003cstrong\u003eTissue Remodeling\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp dir=\"auto\"\u003eExperimental studies involving full-length Tβ4 have demonstrated activity across several of these biological processes.\u003c\/p\u003e\n\u003cp dir=\"auto\"\u003eThis has made Thymosin Beta-4 and related peptide sequences interesting research targets for understanding how cellular migration, cytoskeletal regulation and vascular responses interact during tissue remodeling. \u003cspan class=\"contents\"\u003e\u003cspan class=\"\"\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003chr\u003e\n\u003ch2 dir=\"auto\"\u003eResearch in Impaired Tissue-Repair Models\u003c\/h2\u003e\n\u003cp dir=\"auto\"\u003eThymosin Beta-4 has also been investigated in experimental models in which normal tissue repair is impaired.\u003c\/p\u003e\n\u003cp dir=\"auto\"\u003eAnimal research involving diabetic and aged mice reported increased wound contraction and collagen deposition following Tβ4 exposure. In aged experimental models, researchers also observed changes in keratinocyte migration and wound repair.\u003c\/p\u003e\n\u003cp dir=\"auto\"\u003eA synthetic seven-amino-acid peptide containing the Tβ4 actin-binding domain also demonstrated activity in one of these experimental models.\u003c\/p\u003e\n\u003cp dir=\"auto\"\u003eThese are \u003cstrong\u003epreclinical animal findings\u003c\/strong\u003e and should not be interpreted as demonstrating therapeutic efficacy of TB-500 in humans. \u003cspan class=\"contents\"\u003e\u003cspan class=\"\"\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003chr\u003e\n\u003ch2 dir=\"auto\"\u003ePotential Research Applications\u003c\/h2\u003e\n\u003cp dir=\"auto\"\u003eTB-500 may be of interest for laboratory investigations involving:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\u003cstrong\u003eActin cytoskeleton research\u003c\/strong\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cstrong\u003eCell migration studies\u003c\/strong\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cstrong\u003eCellular differentiation\u003c\/strong\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cstrong\u003eTissue-remodeling pathways\u003c\/strong\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cstrong\u003eRegenerative biology\u003c\/strong\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cstrong\u003eAngiogenesis research\u003c\/strong\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cstrong\u003eEndothelial-cell biology\u003c\/strong\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cstrong\u003eExtracellular matrix research\u003c\/strong\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cstrong\u003eWound-healing models\u003c\/strong\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cstrong\u003eCell adhesion research\u003c\/strong\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cstrong\u003eCytoskeletal dynamics\u003c\/strong\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cstrong\u003eThymosin Beta-4 pathway research\u003c\/strong\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cstrong\u003eExperimental pharmacology\u003c\/strong\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cstrong\u003eMolecular and cellular biology\u003c\/strong\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp dir=\"auto\"\u003eSpecific suitability for individual experimental protocols should be established by qualified researchers using appropriate analytical and batch-specific documentation.\u003c\/p\u003e\n\u003chr\u003e\n\u003ch2 dir=\"auto\"\u003eMechanism of Research Interest\u003c\/h2\u003e\n\u003cp dir=\"auto\"\u003eA simplified representation of the biological pathway associated with the parent Tβ4 molecule can be presented as:\u003c\/p\u003e\n\u003cp dir=\"auto\"\u003e\u003cstrong\u003eThymosin Beta-4 \/ Actin-Binding Region\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp dir=\"auto\"\u003e↓\u003c\/p\u003e\n\u003cp dir=\"auto\"\u003e\u003cstrong\u003eInteraction with G-Actin\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp dir=\"auto\"\u003e↓\u003c\/p\u003e\n\u003cp dir=\"auto\"\u003e\u003cstrong\u003eActin Cytoskeleton Regulation\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp dir=\"auto\"\u003e↓\u003c\/p\u003e\n\u003cp dir=\"auto\"\u003e\u003cstrong\u003eCell Migration \u0026amp; Cellular Organization\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp dir=\"auto\"\u003e↓\u003c\/p\u003e\n\u003cp dir=\"auto\"\u003e\u003cstrong\u003eTissue Remodeling \/ Angiogenesis Research\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp dir=\"auto\"\u003eThis pathway provides a useful framework for understanding why Tβ4-derived sequences have attracted interest in regenerative and cellular research.\u003c\/p\u003e\n\u003cp dir=\"auto\"\u003eHowever, the complete biological activity of full-length Thymosin Beta-4 cannot automatically be attributed to TB-500.\u003c\/p\u003e\n\u003chr\u003e\n\u003ch2 dir=\"auto\"\u003eScientific Evidence and Important Limitations\u003c\/h2\u003e\n\u003cp dir=\"auto\"\u003eThere is a substantial experimental literature investigating \u003cstrong\u003eThymosin Beta-4\u003c\/strong\u003e, particularly in relation to actin biology, cell migration, angiogenesis and tissue repair.\u003c\/p\u003e\n\u003cp dir=\"auto\"\u003eFor example, experimental studies have demonstrated that Tβ4 can influence endothelial-cell migration and angiogenic processes, while animal studies have reported effects on several aspects of wound repair. \u003cspan class=\"contents\"\u003e\u003cspan class=\"\"\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"auto\"\u003eHowever, the evidence specifically involving \u003cstrong\u003eTB-500 itself is considerably more limited\u003c\/strong\u003e.\u003c\/p\u003e\n\u003cp dir=\"auto\"\u003eRegulatory reviews have noted that research and commercial literature sometimes use the names TB-500 and Thymosin Beta-4 interchangeably even though they are not the same substance. Direct human clinical evidence for TB-500 has not established its safety or therapeutic effectiveness. \u003cspan class=\"contents\"\u003e\u003cspan class=\"\"\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"auto\"\u003eThis distinction should be maintained when interpreting research findings.\u003c\/p\u003e\n\u003chr\u003e\n\u003ch2 dir=\"auto\"\u003eProduct Information\u003c\/h2\u003e\n\u003cp dir=\"auto\"\u003e\u003cstrong\u003eProduct Name:\u003c\/strong\u003e TB-500\u003cbr\u003e\u003cstrong\u003eBrand:\u003c\/strong\u003e ICAME Pharmacy\u003cbr\u003e\u003cstrong\u003eProduct Category:\u003c\/strong\u003e Research Peptide\u003cbr\u003e\u003cstrong\u003eResearch Classification:\u003c\/strong\u003e Thymosin Beta-4–Derived Research Peptide\u003cbr\u003e\u003cstrong\u003eResearch Areas:\u003c\/strong\u003e Cytoskeletal Biology \/ Cell Migration \/ Tissue Remodeling \/ Regenerative Research\u003cbr\u003e\u003cstrong\u003eIntended Use:\u003c\/strong\u003e Laboratory Research \u0026amp; Development Only\u003c\/p\u003e\n\u003cp dir=\"auto\"\u003eBatch-specific information including \u003cstrong\u003epurity, analytical methodology, Certificate of Analysis (COA), molecular identity, batch\/lot identification and validated storage conditions\u003c\/strong\u003e should be provided according to the documentation associated with each individual production batch.\u003c\/p\u003e\n\u003chr\u003e\n\u003ch2 dir=\"auto\"\u003eImportant Research Use Notice\u003c\/h2\u003e\n\u003ch3 dir=\"auto\"\u003eFOR RESEARCH USE ONLY (RUO)\u003c\/h3\u003e\n\u003cp dir=\"auto\"\u003eThis product is intended exclusively for legitimate \u003cstrong\u003elaboratory, analytical and scientific research purposes\u003c\/strong\u003e.\u003c\/p\u003e\n\u003cp dir=\"auto\"\u003e\u003cstrong\u003eNot for human or veterinary use. Not for diagnostic, therapeutic, prophylactic, injury-recovery, performance-enhancing or cosmetic purposes. Not for direct administration to humans or animals.\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp dir=\"auto\"\u003eTB-500 is \u003cstrong\u003enot an approved medicinal product\u003c\/strong\u003e. FDA's review also notes the absence of approved TB-500 products in several major jurisdictions and the lack of EU authorization by the European Medicines Agency. \u003cspan class=\"contents\"\u003e\u003cspan class=\"\"\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"auto\"\u003eInformation provided on this page is intended for scientific and educational purposes only and should not be interpreted as medical advice, prescribing information, dosage guidance or evidence of established clinical safety or efficacy.\u003c\/p\u003e\n\u003chr\u003e\n\u003ch2 dir=\"auto\"\u003eAbout ICAME Pharmacy\u003c\/h2\u003e\n\u003cp dir=\"auto\"\u003e\u003cstrong\u003eICAME Pharmacy\u003c\/strong\u003e provides specialized research products intended for professional laboratory and scientific applications.\u003c\/p\u003e\n\u003cp dir=\"auto\"\u003eOur research portfolio focuses on compounds relevant to contemporary areas of \u003cstrong\u003emolecular biology, cellular research, regenerative biology, biochemical research and experimental life sciences\u003c\/strong\u003e.\u003c\/p\u003e\n\u003cp dir=\"auto\"\u003eProduct information is presented with an emphasis on responsible research use, scientific transparency and clear differentiation between experimental findings and established clinical evidence.\u003c\/p\u003e\n\u003cp dir=\"auto\"\u003eFor batch-specific documentation, analytical information and product inquiries, please contact \u003cstrong\u003eICAME Pharmacy\u003c\/strong\u003e.\u003c\/p\u003e\n\u003cp class=\"whatyouget__text\"\u003e \u003c\/p\u003e","brand":"icamepharmacy","offers":[{"title":"Default Title","offer_id":52935340294455,"sku":null,"price":60.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0986\/5458\/5143\/files\/tb500-10mg.jpg?v=1790251024","url":"https:\/\/icamepharmacy.com\/products\/tb500","provider":"Icame Pharmacy","version":"1.0","type":"link"}